全文获取类型
收费全文 | 402468篇 |
免费 | 27368篇 |
国内免费 | 4728篇 |
专业分类
耳鼻咽喉 | 5480篇 |
儿科学 | 8415篇 |
妇产科学 | 10329篇 |
基础医学 | 55676篇 |
口腔科学 | 12104篇 |
临床医学 | 33134篇 |
内科学 | 81177篇 |
皮肤病学 | 8739篇 |
神经病学 | 28427篇 |
特种医学 | 14782篇 |
外国民族医学 | 91篇 |
外科学 | 63421篇 |
综合类 | 15330篇 |
现状与发展 | 5篇 |
一般理论 | 64篇 |
预防医学 | 19012篇 |
眼科学 | 10114篇 |
药学 | 33894篇 |
20篇 | |
中国医学 | 3769篇 |
肿瘤学 | 30581篇 |
出版年
2021年 | 3384篇 |
2020年 | 2537篇 |
2019年 | 3482篇 |
2018年 | 5269篇 |
2017年 | 4179篇 |
2016年 | 4226篇 |
2015年 | 5142篇 |
2014年 | 7028篇 |
2013年 | 8732篇 |
2012年 | 12114篇 |
2011年 | 12148篇 |
2010年 | 7638篇 |
2009年 | 7031篇 |
2008年 | 10857篇 |
2007年 | 11746篇 |
2006年 | 11703篇 |
2005年 | 10712篇 |
2004年 | 9921篇 |
2003年 | 9738篇 |
2002年 | 9227篇 |
2001年 | 29101篇 |
2000年 | 29479篇 |
1999年 | 24258篇 |
1998年 | 5351篇 |
1997年 | 4473篇 |
1996年 | 3938篇 |
1995年 | 3739篇 |
1994年 | 3306篇 |
1993年 | 2972篇 |
1992年 | 16168篇 |
1991年 | 14928篇 |
1990年 | 14270篇 |
1989年 | 14036篇 |
1988年 | 12642篇 |
1987年 | 12131篇 |
1986年 | 11138篇 |
1985年 | 10354篇 |
1984年 | 6925篇 |
1983年 | 5609篇 |
1982年 | 2720篇 |
1979年 | 5477篇 |
1978年 | 3345篇 |
1977年 | 2963篇 |
1975年 | 2636篇 |
1974年 | 3064篇 |
1973年 | 2863篇 |
1972年 | 2828篇 |
1971年 | 2773篇 |
1970年 | 2509篇 |
1969年 | 2543篇 |
排序方式: 共有10000条查询结果,搜索用时 125 毫秒
21.
Comprehensive evidence regarding the treatment of non-anaemic iron deficiency in patients undergoing valvular heart surgery is lacking. This study aimed to investigate the association between non-anaemic iron deficiency and postoperative outcomes in these patients. We retrospectively analysed 321 patients of which 180 (56%) had iron deficiency (defined as serum ferritin < 100 ng.ml-1 or < 300 ng.ml-1 with transferrin saturation < 20%). While the iron-deficient group had lower pre-operative haemoglobin levels than the non-iron deficient group (median (IQR [range]) 134 (127–141 [120–172]) g.l-1, 143 (133–150 [120–179]) g.l-1, p = 0.001), there was no between-group difference in allogeneic red blood cell transfusion. Median (IQR [range]) days alive and out of hospital at postoperative day 90 was 1 day shorter in the iron-deficient group (80 (77–82 [9–85]) days vs. 81 (79–83 [0–85]) days, p = 0.026). In multivariable analysis, only cardiopulmonary bypass duration (p = 0.032) and intra-operative allogeneic red blood cell transfusion (p = 0.011) were significantly associated with reduced days alive and out of hospital at postoperative day 90. Iron deficiency did not exert any adverse influence on secondary outcomes except length of hospital stay. Our findings indicate that non-anaemic iron deficiency alone is not associated with adverse effects in patients undergoing valvular heart surgery when it does not translate into an increased risk of allogeneic transfusion. 相似文献
22.
23.
目的探讨放疗干预对宫颈癌荷瘤小鼠的抑瘤作用及其对辅助性T细胞1(Th1)/Th2细胞比例的影响。方法建立宫颈癌荷瘤小鼠模型,随机分为荷瘤组和放疗组,每组各10只,另设对照组10只。放疗组进行放疗干预14天,荷瘤组和对照组不治疗。放疗后4、6、8、10、12、14天测量肿瘤体积;末次治疗后,ELISA法测定血清干扰素-γ(IFN-γ)、白介素-2(IL-2)、IL-4、IL-10含量;计算抑瘤率、胸腺指数和脾脏指数;HE染色观察肿瘤组织学变化;TUNEL染色观察肿瘤组织细胞凋亡情况;流式细胞术检测脾脏Th1/Th2细胞比例;RT-qPCR和Western blot检测脾脏T盒子转录因子(T-bet)、GATA结合蛋白3(GABA-3)mRNA和蛋白表达。结果与荷瘤组比较,放疗组小鼠4、6、8、10、12、14天肿瘤体积及瘤质量减小,血清IL-2、IFN-γ升高,IL-4、IL-10降低,胸腺指数、脾脏指数升高,Th1细胞比例、Th1/Th2增加,Th2细胞比例减少,T-bet mRNA和蛋白及T-bet/GATA-3表达升高,GATA-3 mRNA和蛋白表达降低(P<0.05)。HE染色显示,荷瘤组肿瘤细胞数量较多,核大深染,无明显坏死;放疗组肿瘤细胞数量减少,出现大量坏死组织。TUNEL染色显示,荷瘤组TUNEL阳性细胞较少,放疗组TUNEL阳性细胞明显增多。结论放疗对宫颈癌荷瘤小鼠具有明显抑瘤作用,可能是通过调节T-bet/GATA-3表达,促进Th1/Th2分化平衡,增强机体免疫功能发挥作用。 相似文献
24.
25.
Yi Su Jean W. Woo Timothy C.Y. Kwok 《Journal of the American Medical Directors Association》2019,20(1):83-89
Objectives
To examine the potential added value of a simple 5-item questionnaire for sarcopenia screening (SARC-F) to the Fracture Risk Assessment Tool (FRAX) for hip fracture risk prediction, in order to identify at-risk older adults for screening with dual-energy x-ray absorptiometry (DXA).Design
A prospective cohort study.Setting and participants
Two thousand Chinese men and 2000 Chinese women aged 65 years or older were recruited from local communities and were prospectively followed up for about 10 years.Measures
Areal bone mineral density (BMD) of hip and lumbar spine were measured by DXA at baseline. Ten-year FRAX probability of hip fracture was calculated using the baseline risk factors. Information from the baseline questionnaire was extracted to calculate a modified SARC-F score. The independent predictive values of SARC-F and FRAX questionnaire were evaluated using multivariate survival analysis. The added predictive values of SARC-F to FRAX for pre-DXA screening were examined.Results
During the follow-up, 63 (3.2%) men and 69 (3.5%) women had at least 1 incident hip fracture. SARC-F had an independent value of FRAX for hip fracture risk prediction, with an adjusted hazard ratio [95% confidence interval (CI)] of 1.24 (1.02, 1.52) and 1.15 (0.99, 1.13) in men and women, respectively. Compared with using FRAX, using SARC-F in conjunction with FRAX made the sensitivity for prediction rise from 58.7% to 76.2% in men and from 69.6% to 78.3% in women, with a nondecreased area under receiver operating characteristic curve of 0.67. Prescreening using FRAX in conjunction with SARC-F could save more than half of the DXA assessment than with no prescreening.Conclusions/Implications
SARC-F is associated with a modest increase in hip fracture risk, especially in men. Conjoint evaluation for sarcopenia in addition to FRAX screening may help identify older adults at higher risk of hip fracture for more intensive screening and/or preventive interventions. 相似文献26.
27.
James I. Geller MD Joseph G. Pressey MD Malcolm A. Smith MD Rachel A. Kudgus PhD Mariana Cajaiba MD Joel M. Reid PhD David Hall PhD Donald A. Barkauskas PhD Stephen D. Voss MD Steve Y. Cho MD Stacey L. Berg MD Jeffrey S. Dome MD PhD Elizabeth Fox MD Brenda J. Weigel MD 《Cancer》2020,126(24):5303-5310
28.
Fang Shengyu Li Yiming Wang Yinyan Zhang Zhong Jiang Tao 《Journal of neuro-oncology》2020,147(2):317-326
Journal of Neuro-Oncology - Glioblastoma (GBM) remains one of the most lethal primary brain tumors in children and adults. Targeting tumor metabolism has emerged as a promising-targeted therapeutic... 相似文献
29.
目的:比较多西他赛联合氟尿嘧啶、顺铂方案与多西他赛联合氟尿嘧啶、洛铂方案治疗晚期不可手术胃癌患者的疗效和不良反应。方法:回顾性分析2015年2月至2018年6月126例晚期不可手术的胃癌患者。洛铂组55例:多西他赛+氟尿嘧啶+洛铂,顺铂组71例:多西他赛+氟尿嘧啶+顺铂。洛铂组和顺铂组均21天为一个疗程,连续治疗四个疗程。结果:洛铂组患者客观有效率为50.91%,顺铂组为35.21%,差异无统计学意义(P>0.05)。洛铂组患者疾病控制率达到83.64%,顺铂组为67.61%,差异有统计学意义(P<0.05)。洛铂组患者在恶心、呕吐、白细胞减少和四肢麻木方面发生率明显低于顺铂组,差异有统计学意义(P<0.05)。洛铂组患者血小板减少发生率高于顺铂组,差异有统计学意义(P<0.05)。洛铂组患者严重不良反应的发生率为21.82%,顺铂组为39.44%,差异具有统计学意义(P<0.05)。结论:将多西他赛联合氟尿嘧啶、顺铂方案中的顺铂以洛铂替代,取得了更好的疾病控制率,而患者的不良反应更轻,严重不良反应的发生率也更低,值得临床进一步研究。 相似文献
30.